HIV感染–免疫动力学的元胞自动机模拟研究

Abstract

自1981年发现首例人类获得性免疫缺失综合症(艾滋病，AIDS)至今已有30多年，然而人们至今未能找到治疗这种危及人类生命健康的可怕疾病的方法。建立正确的艾滋病病毒HIV与免疫系统相互作用数学模型，有助于发现HIV的感染机理，帮助我们找到治疗AIDS的方法。在这篇报告中，我们综述了利用元胞自动机模型来揭示HIV与免疫系统相互作用的研究，包括模拟HIV感染后病人出现三个典型的特征期(急性期、潜伏期和AIDS发病期)的动力学过程，以及对应的药物治疗理论研究。 It is more than 30 years since the first case of Acquired Immune Deficiency Syndrome (AIDS) has been reported. However, we still cannot find the effective treatment though this terrible sickness kills approximately two million patients per year. Using mathematical model for approaching the dynamics of human immunodeficiency virus (HIV) infection was and still is one of most important methods among the numerous studies of the treatments of AIDS. Constructing a correct mathematical model of HIV infection will help us to investigate the interaction between HIV and immune and shed light on AIDS treatment. In this article, we review the recent development of cellular automata model to discuss the interaction mechanism between HIV and immune cells, and the drug treatment.