Hitchcock's experimental series of foetal implants for Parkinson's disease: co-grafting ventral mesencephalon and striatum.

Abstract

Following 4 previous experimental series of foetal implants (mesencephalon) to treat patients with Parkinson's disease subjects (N7) in the fifth series were treated with co-grafts of foetal mesencephalon and striatum implanted stereotactically into the caudate nucleus bilaterally. The clinical outcome, better than in the previous series, included improvements lasting through 18 months follow-up in activities of daily living, clinical neurological motor examination, timed motor tasks, and dyskinesia-with reduction in the patients' need for dopaminergic medication.