Abstract
A two-stage treatment was performed to explore the feasibility of generating histotripsy using hundred-microsecond pulses. A single-element 1.06-MHz transducer was used at 8 MPa peak negative pressure with shockwaves. Stage 1 was performed to accelerate the rupture of local tissue structure by boiling bubbles. The pulse group had 500-µs/400-µs pulse duration (PD) and 100-Hz pulse repetition frequency (PRF) with 4.9%/3.9% duty cycle (DC). Stage 2 involved the mechanical homogenization of the lesion by inertial cavitation. Several locations in the lesion axial direction were treated simultaneously by the bubble clusters induced by multiple reflection of shocks. The pulse group had 500-µs/400-µs PD with 100-Hz PRF and 200-µs PD with 200-Hz PRF with 1%/0.88% DC. Experiments were conducted on polyacrylamide phantoms with bovine serum albumin and on rabbit liver tissues ex vivo. Final lesions had a cylindrical shape with smooth borders and total homogenate inside. These results demonstrated that hundred-microsecond pulses enabled controllable histotripsy with a lower acoustic pressure.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
