History of transient ischaemic attack, myocardial infarction and hyperlipidaemia affects outcome following carotid artery stenting.

Abstract

This prospective registry study was intended to evaluate outcomes and predictors of adverse events following carotid artery stenting (CAS). Patients received neurological and duplex exams before CAS, prior to discharge and at 30- and 180-day follow-up. Multiple regression analysis included patient- and procedure-related characteristics. The MACCE endpoint comprised stroke, myocardial infarction and death. Three hundred and seventy-five consecutive patients underwent CAS between 1998 and 2011. Mean age was 69±9.1 years; 53% were symptomatic within the preceding six months. Mean time to CAS was 23 days in patients with TIA and 31 days with stroke (p=0.029). The MACCE rate was 1.6% during intervention and 4.0%, 5.6% and 5.9% at discharge, day 30 and day 180, respectively. TIA occurred in 31 cases (9.6%) within 30 days. A history of TIA was independently associated with MACCE (OR: 2.88; p=0.04). Furthermore, a history of hyperlipidaemia (OR: 4.02, p=0.029), MI (OR: 2.93, p=0.007) and age ≥70 (OR: 1.89, p=0.033) were independent predictors for the combined endpoint MACCE plus TIA. TIA is an underappreciated adverse event following CAS. Pre-procedural TIA was an independent risk factor for adverse outcomes, while stroke was not, probably related to the timing of the procedure relative to the index event.