Historical Vignettes in Heart Failure

Abstract

Congestive Heart FailureVolume 13, Issue 6 p. 346-346 Free Access Historical Vignettes in Heart Failure First published: 19 December 2007 https://doi.org/10.1111/j.1527-5299.2007.06254.xAboutSectionsPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinked InRedditWechat History of Heart Failure “The experiments carried by us in this paper have established that a pressure-raising substance is formed in the kidney, which provides its effect essentially on the peripheral vascular nerve centers…to call this substance for the sake of brevity, by the name of renin. . . .”1 Commentary Robert Tigerstedt, professor of physiology in Stockholm, put forward that the manifestations of uremia were related to some systemic secretion of the kidney. Thus, in a paper with P. G. Bergman published in 1898, he described the discovery that a rabbit renal cortical extract had a prolonged pressure action. The authors wrote that there is “…a blood pressure-raising substance formed in the kidneys and passed into the blood . . . to call this substance . . . by the name of renin. . . .” This landmark publication at the end of the 19th century marks the beginning of the understanding of the role of the renin-angiotensin system in cardiovascular medicine. References 1 Tigerstedt R, Bergman PG. Niere und kreislauf. Skand Arch Physiol. 1898; 8: 223– 271. Wiley Online LibraryGoogle Scholar Volume13, Issue6November/December 2007Pages 346-346 ReferencesRelatedInformation