Abstract
Tools for the assessment of jaundice in neonates have evolved exponentially over the past decades. Tracking the milestones in these developments reveals the striking paradigms and the many parallels in the development of other clinical methods. Great progress has been achieved over the last 100 years in the development of noninvasive methods for diagnosing indirect hyperbilirubinemia in the neonate, from simple visual assessment to the most advanced noninvasive devices that provide accurate measurements when compared to the gold standard blood test (ie, serum bilirubin).
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