Histoplasmosis or tuberculosis in HIV-infected patients in the amazon: what should be treated first?

Mathieu Nacher,Emilie Mosnier,Julie Dufour,Emilie Sambourg,Florence Huber,Magalie Demar,Philippe Abboud,Vincent Vantilcke,Pierre Couppié,Félix Djossou,Antoine Adenis,Loïc Epelboin

doi:10.1371/journal.pntd.0003290

Mathieu Nacher, Emilie Mosnier + Show 10 more

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https://doi.org/10.1371/journal.pntd.0003290

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Abstract

Histoplasmosis or tuberculosis in HIV-infected patients in the amazon: what should be treated first?

Highlights

Histoplasmosis and tuberculosis in HIV patients often are disseminated infections with a fatal evolution in the absence of treatment
Patients with severe disseminated histoplasmosis are at risk of early death within days of their admission, notably if there is treatment delay
The diagnosis of histoplasmosis was performed according to the European Organisation for Research and Treatment of Cancer (EORTC) criteria [12]

Summary

Introduction

Histoplasmosis and tuberculosis in HIV patients often are disseminated infections with a fatal evolution in the absence of treatment. Patients with severe disseminated histoplasmosis are at risk of early death within days of their admission, notably if there is treatment delay. Early mortality in severely immunocompromised patients is a problem and has led to promote early rather than late initiation of antiretroviral therapy [7].

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