Abstract
We studied histophysiological changes in organs of the immune system, liver, and lungs of Wistar rats at delayed terms after ovariectomy. On day 52 after surgical castration leading to a decrease in estradiol, progesterone, and testosterone levels, activation of the immune system was revealed characterized by stage I accidental thymus involution, while pulp depletion in the spleen, and enhanced IL-2 and IFN-γ production. We also observed small-droplet degeneration of hepatocytes and reactive changes in the lungs manifested in increased number of neutrophils in the interalveolar septa.
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