Abstract
Investigators from Sainte Justine Hospital (Montreal), Montreal Neurological Hospital and Institute, King's College Hospital (London), and John Radcliffe Hospital (Oxford) retrospectively reviewed medical records, autopsy reports, and genetic studies containing "Polymicrogyria."
Highlights
The brain surface was abnormal overlying the polymicrogyric cortex in 87% of the cases
Other genetic associations with PMG have been reported in the literature (PI3/Akt) which resulted in concomitant PMG and hemimegalencephaly
Etiology was only assigned to one category, there is an overlay of histopathologic features amongst all three categories
Summary
The brain surface was abnormal overlying the polymicrogyric cortex in 87% of the cases. The leptomeninges were abnormal in 86% of those patients, some showing glial invasion. The majority of cases in which the leptomeninges were abnormal had either a genetic, ischemic, or infectious etiology. In the cases where the leptomeninges were normal, the underlying pia had pathology in a subset of cases (disruption, thickening, subpial gliosis).
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