Histopathological Variants of Ovarian Tumors and Their Presentation in Rural Tertiary Care Center of Northern India: An Observational Study

Abstract

Ovarian cancer is one of the common gynecological cancers with high mortality rates. The study was conducted to know prevalence, histopathological variants, presentation and outcome in women with ovarian tumors. Present study was conducted in Obstetrics and Gynecology department of rural tertiary center over one year (December 2017–November 2018) on women with unilateral/bilateral ovarian masses fulfilling inclusion criteria. Demographic features including age, parity, nature, laterality and histopathological variants were analyzed and compared. Statistical analysis was done using SPSS 20.0 version software. Of 122 cases, 49 (40.2%) had benign tumors, 05 (4.1%) borderline, 64 (52.5%) primary malignant tumors and 04 (3.3%) secondary metastatic deposits. Majority of the women (60.3%) with malignant tumors presented at stage II/III. Most of the women (89.8%) with benign tumors had unilateral lesions, and 64.1% women with malignant tumors had bilateral masses (p < 0.05). Both benign (59.1%) and malignant (87.0%) unilateral ovarian masses were more common on right. CA125 was significantly higher in women with malignant tumors as compared to benign (p = 0.024) and borderline tumors (p = 0.386). On histopathological examination, most common malignant ovarian tumor was serous cystadenocarcinoma (39.1%) and in benign mature teratomas (42.9%). Diabetes mellitus was significantly associated with malignant ovarian tumors (p = 0.016). Epithelial ovarian tumors were most common malignant tumors and mature teratomas most common benign tumors. Ovarian malignancies present at advanced stage and have high mortality.