Abstract
Results: It was observed that the repeated application of DMBA alone and repeated application of TPA after single application of DMBA produced both epidermal and dermal tumours like papilloma, dysplasia, keratoacanthoma, squamous cell carcinoma in situ, extensive squamous cell carcinoma, and fibrosarcoma. The malignant varieties of skin tumors were 30 % more with the repeated application of DMBA alone than that by repeated application of TPA after single application of DMBA. The statistical analysis of cellular DNA, RNA and proteins concentrations estimates were found comparatively significant in experimental groups. Conclusion: The contact of DMBA (a compound of coal tar) can act as initiator as well as promoter for skin tumourigenisis. Abbreviations: ¤ DMBA (Dimethyl Benz anthracene) is derived from anthracene i.e. poly-aromatic hydrocarbon found in commonly used coal tar.¤¤ TPA (tetradecanyl phorbol acetate) is derived from acetate that is salt or ester of ethanoic acid manufactured by oxidation of ethanol and commonly used for production of vinegar.
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