Abstract
In recent years, there has been a great deal of attention toward the field of free radical chemistry. Free radicals reactive oxygen species and reactive nitrogen species are generated by our body by various endogenous systems, exposure to different physiochemical conditions or pathological states. A balance between free radicals and antioxidants is necessary for proper physiological function. If free radicals overwhelm the body’s ability to regulate them, a condition known as oxidative stress ensues. Free radicals thus adversely alter lipids, proteins, and DNA and trigger a number of human diseases. This study was designed to determine the influence of Glutathione to reduce the pathological changes induced by estrogen. In this study 40 female and male mice are taken at age of 21days with groups of control (10 mouse in each group).The group of experimental animals was treated with estrogen and glutathione diluted with distilled water, as a vehicle, and injected intraperitonially for 12 weeks, once weekly. Each control group was injected with the vehicle of it in the same manner of injection and for the same period.
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