Abstract
Bee venom (BV) of Apis mellifer L has recently been utilized as a traditional medicine for treating a variety of medical conditions. When mice were given different concentrations of bee venom, it was found to be effective in repairing some histopathological changes. Then, when applying BV as a treatment material for some disorders, as indicated by the amount of damage to the liver and kidney tissues. The animals were randomly divided into 7 groups. Six of which were treated with BV extraction, and one group was designated as the control group, was treated with distilled water. Mice were injected intraperitoneally by 0.2ml of BV extraction in concentrations (1000, 750, 500, 350, 300, and 250) μg/ml. In some cases, histopathological studies revealed mild to moderate alterations in the liver and renal tissues, characterized by congestion, acute cell swelling, and focal coagulated necrosis. Atherosclerotic changes in the aorta and some arteries were found in two groups. Whereas several mild degenerative changes were observed in hepatic cells of one group. In conclusion, bee venom administered to groups in different concentrations revealed hepatic and renal complications at histological investigations of hematoxylin and eosin-stained sections of liver and kidney section.
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