Abstract
To report the first histopathological examination of an explanted KeraKlear keratoprosthesis device and surrounding host corneal tissue 1 year after transplantation. An explanted KeraKlear artificial cornea was evaluated by histopathology to assess for tissue integration and corneal remolding. Histopathological examination revealed collagenous ingrowth between the anterior and posterior corneal stromal lamellae through the holes in the device skirt. Hematoxylin and eosin stain (H&E), periodic acid Schiff (PAS), and Masson trichrome stains demonstrated no significant inflammation, vascularization, or edema. The KeraKlear artificial corneal device seems to be a biocompatible alternative to donor corneal tissues for visual rehabilitation for suitable patients.
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