Abstract
A ten weeks old male Swiss Albino mice from a safety assessment study was found with growth at hind leg in the subcutis near inguinal region during necropsy. Tissue was collected, fixed, processed, embedded in paraffin and sliced to produce histology slide. Microscopically, mass was composed of multiple nodules of tumour cells that were incompletely encapsulated with fibrous connective tissue. The neoplastic cells appeared as immature spindles of striated muscle, mononucleated, rounded and polygonal cells with minimal to abundant eosinophilic cytoplasm. Areas of large, multinucleated cells, strap-like cells and a few vacuolated cells were also present. Based on the pathology results, growth was diagnosed as a spontaneous rhabdomyosarcoma in a young mouse.
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