Abstract
In rats, the effect of phenobarbital Pre-treatment on the toxicity of a variety of halogenated organic solvent has been investigated. The current findings show that Phenobarbital pre- treatment significantly reduces the toxicity of toluene and trichloroethylene. Our observations Show that toluene is more hepatotoxic than trichloroethylene. It causes peculiar ultra-structural changes i.e. involution of nuclear membrane and irregular arrangement of mitochondrial cristae. However, using single high- dose levels of these solvents, a potentiating impact of Phenobarbital on the toxicity of other organic solvents such as methanol, xylene, and methylene chloridecould not be demonstrated. Because barbiturates are commonly used by industrial workers, it’s crucial to be aware of the possibility of synergistic effect from inhaling of organic solvents, as well as of potentiation associated with others.
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