Histopathological studies on the effect of bacteriocin producing Bacillus cereus isolate from ‘wara’ a local soft cheese on the liver, kidney and reproductive organs of Wistar albino rats

Abstract

10 4 CFU of B. cereus showed diffuse hydropic degeneration and portal congestion of the liver while at 10 4 CFU the kidney showed diffuse, moderate interstitial cellular infiltration. This is more evident in the wistar rats administered with bacilli organism than the groups that received the bacteriocin. The reproductive organs of treated animals showed no pathological lesions. There were no visible tissue pathological changes in the untreated groups. There were no visible tissue pathological changes in the untreated groups. Conclusion, significance and impact study: The absence of observable toxic effects of the bacteriocin of B. cereus on the sex organs, is not sufficient to determine the safety of this bacteriocin since pathological lesions were observed in the liver and kidney. We hereby suggest a further study on characterization and purification of this bacteriocin as a biopreservative in items not meant for human use or consumption.