Histopathological spectrum of breast lesions in association with Histopathological Grade versus Estrogen receptor and Progesterone receptor status in breast cancers : A Hospital based study

Abstract

Background:  A retrospective study of 2-years duration from January 2015 to December 2016 was undertaken to evaluate the histopathological spectrum of breast lesions including both the benign breast lesions and malignant breast lesions. To evaluate the Estrogen receptor and Progesterone receptor status in breast cancer cases by using immunohistochemistry and is to correlate the histopathological grade with ER, PR status of breast cancer. Methods: The histopathological findings of the 132 biopsied Specimens of all age groups and both sexes were studied and most of them were lumpectomy specimens and few were mastectomy specimens. IHC markers were applied on breast cancer cases. Results: Out of the 132 cases benign breast lesions constituted 78.78% and malignant breast lesions 21.22%. Among the benign breast lesions fibro adenoma was the commonest and among the malignant breast lesion, infiltrating ductal carcinoma was commonest. The peak incidence of benign breast lesion was in 11 to 40 years and malignant lesion in 41 to 70years. Out of 22 cases of infiltrating ductal carcinoma, 27.27% cases showed both ER, PR positivity and 63.64% cases showed both ER, PR negativity. A significant association was seen between histologic grade and ER, PR status. Conclusion: In our study fibro adenoma was the commonest benign breast lesion and infiltrating ductal carcinoma was the predominant malignant breast lesion. Among the breast cancers, both ER and PR negativity cases were predominant and low grade tumors were showing high ER, PR expression and high grade tumors were showing low ER, PR expression in our study.  DOI: 10.21276/APALM.1378