Abstract
This study determined the effect of Mango mistletoe Methanolic Extract (MMME) on the cardiac's histopathological profile of hypertensive rats (DOCA-Salt) treated. The MMME was treated on fifty rats for 14 days, divided into five treatments: negative control, positive control, doses 50, 100, and 200 mg/kg BW with five replications. One-way ANOVA analysis was used, namely JAMOVI with version 1.1.9.0, and for cell calculation, diameter using the IMAGE J application. Results showed that there were no significant differences in the histopathological profile of the cardiac in hypertensive rats (DOCA-Salt) treated with MMME for 14 days on the diameter of the heart muscle cells between the control (+) and control groups (-), treatments 1, 2, and 3. This is evidenced by the analysis of p-value> 0.05, namely 0.187 millimeters. Therefore, we concluded that MMME does not affect the diameter of heart/cardiac organ muscle cells. However, there was a significant difference in the amount of necrosis in the cardiac of hypertensive rats between control (+) and control (-) groups, treatments 1, 2, and 3. Based on the results, MMME reduces the number of necrosis in the heart/cardiac organ.
Highlights
Indonesia is the second-largest biodiversity in the world after Brazil, which consists of tropical plants and marine biota
Mango Mistletoe Methanolic Extract (MMME) was exposed to male Wistar rats (Rattus norvegicus) for 14 days and clinical biochemical examination of heart function and histopathological observations of male Wistar rats were carried out
The exposure to Mango Mistletoe Methanolic Extract (MMME) for 14 days reduced the mean number of necrosis in hypertensive rats' heart organs (DOCA-Salt)
Summary
Indonesia is the second-largest biodiversity in the world after Brazil, which consists of tropical plants and marine biota. There are about 30,000 types of plants, 7,000 of them have medicinal properties. Mango mistletoe (D. pentandra) is widely used in the traditional medical world. Mango parasite (Dendropthoe petandra) have been reported has potential activity as anti-plasmodium [2]. The mango parasites contain some active substances, including flavonoids, amino acids, carbohydrates, tannins, saponins, alkaloids [5,6]. It is used to treat coughs, hypertension, diabetes, cancer, stomach ulcers, measles, diuretics, skin infections, and postpartum conditions [8 - 11]. The mango seeds reported as an anti-colon cancer agent [3], and the mango parasite extract reduces cholesterol and LDL levels and suppress hypertension [4]
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