Abstract
Background: Sinonasal lesions are a common finding in Otorhinolaryngology outpatientdepartment. Most commonly they present withnasal obstruction. Clinically many of these lesions resemble eachother but they have multiple differential diagnosis ranging from congenital, inflammatory, traumatic to neoplasticcauses that needs histopathological confirmation. Objectives: This study was undertaken to study the various histopathological patterns of sino-nasallesions, theirclassification and relative distribution of various lesions with regard to age and sex in our setting. Material and Methods: This was a retrospective study of Sino-nasal lesions specimens thatwas received at histopathology section of Department of Pathology, Hamdard Institute of Medical Science andResearch andover a period of two years from June 2014 to May 2016. Results: A total of 62 cases of sino-nasal lesions were reported during the study period. Ageranged from 5 years to 75 years with malepredominance. Among all the lesions forty five (45) were non-neoplastic, ten (10) benign and seven (7) were diagnosedas malignant tumors. Inflammatory polyp was the commonest non-neoplastic lesion while Sinonasal Papilloma was the commonest benign lesion and Sinonasal carcinoma was themost common malignancy. Conclusions: Sino-nasal lesions comprises of wide spectrum of lesions but their presenting clinicalmanifestations are very limited. Hence, on the basis of clinical picture various nonneoplastic, benign and malignantlesions may mimic each other. Histopathological diagnosis forms the mainstay of diagnosis in these lesions whichmay even reveal clinically unsuspected rare malignancies as seen in our study.
Highlights
The nasal passage and paranasal sinuses collectively termed Sino-nasal area serves as host to a variety of diseasedconditions known as sino-nasal lesions that are commonly seen in Otorhinolaryngology outpatient department
Most of the sino-nasal lesion presented with nasal obstruction whichwas the commonest symptom fo llo wed by nasal discharge and epistaxis
Sino-nasal lesions comprise of wide spectrum of lesions but their presenting features are mostly overlapping andlimited in nu mber
Summary
Sinonasal area along with nasopharynx constitute the functional unit that is lined by stratified squamous epitheliu m, pseudostratified colu mnar epitheliu m and intermediate (t ransitional) epitheliu m andis principally involved infiltering, humidifying and adjusting temperature of inspired air [1,2] Exposure of these areas to various infectiveagents, chemicals, antigens, mechanical and many other influences leads to Manuscript received: 7th October 2017 Reviewed: 17th October 2017 Author Corrected: 26th October 2017 Accepted for Publication: 1st November 2017 development of variety of non-neoplastic and neoplastic lesions [3]. Other symptoms include nasal discharge, epistaxis, disturbances of smell These sinonasal lesions can have various differential diagnosis that may becongenital, inflammatory, neoplastic or traumat ic. Sinonasal lesions are a common finding in Otorhinolaryngology out patient department Histopathological diagnosis forms the mainstay of diagnosis in these lesions which may even reveal clinically unsuspected rare malignancies as seen in our study
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