Abstract
The aim of the present study was to find out histopathological alterationsassociated with rabies in nervous tissue of animals. Samples from 6 different species were collected, i.e., 22 dogs, 16 buffaloes, 7 cows, 1 donkey, 3 mongoose (Herpestes edwardsii) and 1 samber (Rusa unicolor). Out of 28 positive cases, 12 were dogs, 9 buffaloes, 3 cows, 3 mongooses and 1 donkey. Twenty eight (56%) cases were found to be positive for rabies by Fluorescence Antibody Technique (FAT). While 19 cases (38%) were detected positive by demonstration of Negri bodies though histopathological examination. In comparison to FAT, histopathology revealed 64.28% sensitivity. Histopathological alterations associated were Babes’ nodules, satellitosis, spongiosis, vacuolation in neurons,neuronophagia, gliosis, neuronal degeneration, congestion, perivascular cuffing, hemorrhages, oedema and meningitis. It was concluded that detection of Negri bodies was quite consistent in buffalo and cows as compared to the dogs. Cerebellum is the most reliable site for detecting Negri bodies in the case of buffalo and cows and hippocampus in the case of dogs.
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