Histopathological Evaluation of Di-Ethyl Phthalate Induced Hepatotoxicity on Rat

Abstract

Hepatotoxicity in one of the major parameters need to be consider in drug therapy, behind the reason that drugs given either in single or in combination for a prolonged period causes liver damage. Most of drug withdraw from the market or pending for approval due to causing hepatotoxicity (Leflunomide, Flutamide, Disulphiram, and Triglitazone) and may be chance to criticize the use based on this toxicity. Hepatoprotective agent opposes this effect while the agent who generates called hepatotoxins. There is no plant in this Universe which is non-medicinal and which cannot be made of use for many purposes and by many modes. This definition rightly suggests that in principle all plants have a potential medicinal value. Medicinal plants have been considered as important therapeutic aid for alleviating ailment of humankind. The present review is aimed at compiling data on promising Phytochemical from medicinal plants that have been tested in hepatotoxicity models using modern scientific system and mechanisms of free radicals toxicity with scavenger which revealed their toxicity belongs to synthetic or herbal product.