Histopathological Effect of (Peganum harmala) Alcoholic Extract of Seeds on Liver and Kidney in Mice

Abstract

Toxicity still a global problem for the environment, agriculture and ultimately human health. The purpose of the study was to examine toxicity effects of Peganum harmala herbal extract on liver and kidney of albino Swiss mice. The herbal alcoholic extract used in different doses (1000, 2000, and 3000 mg/kg b.w) for 2 weeks. The liver and kidneys dissected out and quickly fixed in 10% formal saline for histologic study. The result indicated that the treated sections of the liver showed congestion of central vein surround the hepatic lobules with sever infiltration of inflammatory cells. In addition, the Kidneys showed congestion of blood vessels with enlargement of glomerular tuft and mild-severe infiltrate of chronic inflammatory cells compared to the control. The findings indicated that the administration of Peganum harmala extract has some adverse effects on the liver and kidneys of adult mice. The study showed that alcoholic herbal extract exposure might cause harmful effects to no target organisms, including humans. Finally, further studies may be carried out to examine toxicity effects for other herbal extract to induce the safety dose dependent to histopathological changes in the liver and kidney tissues of exposed mice.