Histopathological effect of different concentration of powder detergent on the laboratory mice ( Mus musculus ) intestine

Abstract

Eighty mice (Mus musculus) were ingested with various concentration of powder detergent and the Histopathological changes were measurd of different concentration of Powder detergent by ingesting 80 mice Mus musculus strain (4-8) weeks aged with detergent solutions. mice were divided into (8) groups ,each one composed of (8) mice. The control group (H) were ingested vegetables (celery) only, while the groups (A,B,C,D,E,F,G) were ingested vegetables (celery), which soaked in aqueous solution of Powder detergent with various concentrations of Powder detergent for different times (1.5g/Kg15min, 3g/Kg15min, 4.5g/Kg15min, 1.5g/Kg30min, 3g/Kg30min, 4.5g/Kg30min, 1.5 g/Kg1-2min). The intestine tissue of the exposed mice showed marked Histopathological changes induced in the intestine of mice by detergent included Many intestinal microvilli were ruptured near the tips, lesions of Epithelial cells of microvilli, Elongation of vili, Degeneration, Lymphocyte infiltration, vacuolation and Necrosis. The effects increased by increasing of concentration the detergent solutions Consecutively 4.5g/Kg30min, 3g/Kg30min and 1.5g/Kg30min, were, more than 4.5g/Kg15min, 3g/Kg15min and 1.5g/Kg15min and duration when compared to control (H) group. The results of this research have shown that the detergent is toxic to the mice exposed. the results of the study emphasize healthy hazards of detergent exposure, so needs a proper handling and disposal them during daily life using Finally, it is hoped that the result from this investigation will enlighten people on the health risk posed by detergent.