Abstract
The present study aimed to discover the histopathological of the Monosodium glutamate (MSG), and Sodium nitrite (NaNO2), on the embryonic development of the eyes of albino mice Mus musculus. On the fourteenth and eighteenth day of pregnancy, the stage of organogenesis in these animals. A concentration of 9 g/kg of MSG, a concentration of 110 mg/kg of NaNO2, and the interaction between them used. The results of the study showed the presence of pathological changes to the eyes of the fetuses. The eye on the 14th day of pregnancy, when 9 g/kg of MSG used, there were retinal duplication, increased vascularization in the retina, condensation of some nuclei of the inner nuclear layer and ganglion cells, and necrosis in the vicinity of the lens. When treating with NaNO2 110 mg/kg, there was an irregularity in the lens, corneal distortion, hyperplasia of the retinal nerve tissue. When the two materials overlapped, the corneal tissue necrosis, the lens fiber, and the inner plexiform layer were observed. On the 18th day of pregnancy, when treated with MSG 9g/kg, the most significant overall and striking damage was retinal duplication and optic nerve necrosis. When treated with NaNO2 110 mg/kg, the corneal stroma and dissociation were seen in the photoreceptor cells. In the case of their overlapping, extensive necrosis and reduction appeared in all layers of the retina. The study concluded that consuming MSG and NaNO2 more than the permissible limit during pregnancy leads to tissue lesions harmful to the eye.
Highlights
Food additives can be defined as industrial or natural compounds added to food and are widely used in the food industries to increase the shelf life of the product and improve certain qualities in food, including coloring, preservation, and sweetening
They have negative aspects, and some of them have been prohibited for their toxicity [1]. One of these substances widely used in the world is Monosodium glutamate (MSG), a substance that improves food flavor
When pregnant mice were treated with NaNO2, there was an irregularity of the lens, deformation of the cornea, thinning of the central part of it, hyperplasia of the retinal nerve tissue, and necrosis of the inner plexiform layer (Figure 5)
Summary
Food additives can be defined as industrial or natural compounds added to food and are widely used in the food industries to increase the shelf life of the product and improve certain qualities in food, including coloring, preservation, and sweetening. When pregnant mice were treated with NaNO2, there was an irregularity of the lens, deformation of the cornea, thinning of the central part of it, hyperplasia of the retinal nerve tissue, and necrosis of the inner plexiform layer (Figure 5) This tissue damage may lead to a defect in the eye's fetal development process, which may cause a defect in the visual process after birth. When pregnant mice were treated with NaNO2, there was an irregularity of the lens, deformation of the cornea, hyperplasia of the retinal nerve tissue, and necrosis of the inner plexiform layer We find other previous studies on the effect of MSG alone and NaNO2 alone but not their overlap, and we believe that most of our results were recorded for the first time to our knowledge
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