Abstract
IntroductionSubmandibular glands are exposed to many effects due to diseases and therapeutic interventions. A study evaluating the effect of submandibular gland dysfunction on the parotid gland has not been presented in the literature. ObjectiveThe aim of this study was to evaluate the histopathological changes in the parotid gland following submandibular gland failure. MethodsThree groups of seven randomly selected female New Zealand rabbits weighing 2500–3000g were studied. Unilateral and bilateral submandibular glands were removed in Groups 1 and 2, respectively. No procedure was performed in Group III, the control group. The parotid glands were removed 30 days later. Histological parameters were evaluated and graded between 0 (none) and 3 (severe). Differences between groups were compared using the Mann–Whitney U test. ResultsMean mucus accumulation in acinar cells was 2.57±0.53 and 1.71±0.75 in Groups 1 and 2, respectively (p<0.05). This value was 0.57±0.53 in Group 3, which was significantly lower than in Groups 1 and 2 (p<0.05). Mean dilatation of the intercalated ducts’ lumen was 1.28±0.48 and 1.57±0.53 in Groups 1 and 2, respectively (p>0.05). This value was 0.28±0.48 in Group 3, which was significantly lower than in Groups 1 and 2 (p<0.05). Mean mucus accumulation in the intercalated ducts’ lumen was 2.00±0.81 and 1.00±0.57 in Groups 2 and 3, respectively (p<0.05). ConclusionThe findings of this study indicate that only 1 month after submandibular gland failure, the parotid glands exhibit significant changes.
Highlights
Submandibular glands are exposed to many effects due to diseases and therapeutic interventions
In the lack of a study evaluating the effect of any major salivary gland dysfunction on the other salivary glands, our aim was to evaluate the histopathological changes of the parotid gland in a rabbit model of impaired submandibular gland function
Group III: No surgical intervention was performed on the submandibular glands, and bilateral parotid glands were removed for histopathological examination
Summary
Submandibular glands are exposed to many effects due to diseases and therapeutic interventions. A study evaluating the effect of submandibular gland dysfunction on the parotid gland has not been presented in the literature. Objective: The aim of this study was to evaluate the histopathological changes in the parotid gland following submandibular gland failure. Mean mucus accumulation in the intercalated ducts’ lumen was 2.00 ± 0.81 and 1.00 ± 0.57 in Groups 2 and 3, respectively (p < 0.05). The major salivary glands are exposed to a number of factors which leads to loss of function. In the lack of a study evaluating the effect of any major salivary gland (or glands) dysfunction on the other salivary glands, our aim was to evaluate the histopathological changes of the parotid gland in a rabbit model of impaired submandibular gland function Some of these factors such as botulinum toxin injection, gland excision, and gland transfer are intended for therapeutic purposes.2---4 Salivary gland stones, radiotherapy applied to the head and neck region, and salivary gland trauma cause significant dysfunctions.5---7 In the lack of a study evaluating the effect of any major salivary gland (or glands) dysfunction on the other salivary glands, our aim was to evaluate the histopathological changes of the parotid gland in a rabbit model of impaired submandibular gland function
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