Abstract
This work was devoted to the study of histological changes in the gastrochemius muscles and their nerve apparatus in experimentally induced osteomyelitis of the tibia. It was revealed in experiments with rabbits that a number of changes take place both on the affected side and in the healthy extremity. These changes are manifested in stimulation and degeneration of the nerve apparatus of the muscles which are more pronounced on the side of the lesion. Bilateral atrophies, deformations and inflammatory changes of the muscle fibers are observed. Changes on the healthy extremity are apparently of reflex origin. Excessive regenerative processes in the nerve apparatus of the muscles enhance dystrophic changes. Sleep induced by drugs and vitaminization of the nerves were applied in the third and fourth series of experiments. It was demonstrated that the change of the functional condition of the peripheral and the central portions of the nervous system increase the compensatory adaptation of the organism and decrease the tissue dystrophy. This evidently points to the reflex mechanism of the pathological changes described above and of the compensatory phenomena as well.
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