Histopathological changes in few digestive organs affected by Corynebacterium pseudotuberculosis

Abstract

The microorganism Corynibacterium pseudotuberculosis was studied in this research to show its effect as antigen on some organs of the digestive system and it was observed that its influence is ranged from sever to no effect in the case of using the bacterium as an antigen on the health of the rabbits after particular period of time. The evaluation occurred through histopathological examination. Hepatic cells showed reflection to the antigen by causing inflammation cells appearance at the liver tissues and revealed mononuclear cells infiltration composed mainly of lymphocytes and macrophages after injecting the antigen intra peritoneal, stomach cells as well showed the same trend by presenting infiltration with macrophage and lymphocyte cells, but intestine tissues revealed prominence of goblet cells with moderate mononuclear cells in lamina properia mainly consist of plasma cell and macrophages, villus lining with clear columnar enteric cyst associated with moderate hyperplasia of sub-mucosal gland without an evidence of inflammatory response. For the spleen, it was clear that splenic tissues revealed spleen parenchyma revealed various degree of lymphoid depletion with destruction of lymphoid tissues, and spleen parenchyma revealed reactive hyperplasia, finally, tissues of the gall bladder showed moderate epithelial hyperplasia with diffuse mononuclear cells infiltration in lamina properia