Histopathological and reproductive effect of tamsulosin and finasteride on induced Benign prostate hyperplasia in mice

Abstract

The prostate hyperplasia (BPH) was induced in male mice by subcutaneous injection of testosterone propionate (20 mg/kg) for 30 days. Fifty mice were divided equally into five groups, the first group (G1) was (negative control group), and the second group (G2) was (positive Control group) induced BPH previously and inoculated orally distilled water. The third group (G3) was induced BPH and treated orally with tamsulosin (0.156mg /kg), the fourth group (G4) was induced BPH and treated orally with Finasteride (1.495 mg /kg) and finally, the fifth (G5) was induced BPH and treated orally with a combination of tamsulosin and finasteride (0.0825, 0.7475) mg/kg respectively. The histopathological results showed prostate hyperplasia and abnormal proliferation of the epithelial and stromal cells with inflammation cells accompanying stenosis of acini in G2. Whereas showed a decrease in hyperplasia, and epithelial layer thickness in G3 and G4. Furthermore, prostate shrinkage and the glandular cavities trended towards the normal approach of the prostate in G5. The testosterone levels in G2 showed a significant increase (P<0.05) as compared to other treated groups with a more significant decrease in G4 compared to other treated groups.