Abstract
ABSTRACT The immunophenotype is regarded as an independent prognostic factor in high-grade lymphomas, seeing that lymphomas of T-cell origin are associated with shorter survival time. Although a number of studies have evaluated the immunophenotypical profile of lymphoma in the USA and Europe, Brazilian research on the matter remains scarce. Exact characterization of the histopathological type is crucial to establish proper treatment and prognosis. This study evaluated the database of immunohistochemistry laboratories that perform immunophenotyping of canine lymphoma in Brazil. A total of 203 cases of multicentric lymphoma were classified according to the WHO classification. Immunophenotyping was able to identify 71.4% lymphomas of B-cell line, 27.1% of T-cell line and 1.5% of non-B cells and non-T cell lines. Diffuse large B-cell lymphoma was the most common with 59.1% of the cases. Among T-cell lymphomas, lymphoblastic was the most common (11.33% of the cases). Even though canine lymphomas tend to be high-grade, indolent lymphomas comprised 11.82% of the cases and T-zone lymphoma was the most prevalent (8.86%). The immunophenotype of multicentric lymphoma in Brazil is similar to those in other parts of the world, which suggests similar etiologic factors to the development of this disease.
Highlights
Lymphoma is regarded as the most common hematopoietic neoplasm of dogs and serves as a model of comparison with human non-Hodgkin lymphoma, due to their similarities in frequent histological and immunophenotypical types (Ponce et al, 2010; Vezzali et al, 2010; Curran and Thamm 2016)
From January 2012 to December 2016, 203 cases of multicentric lymphomas according to the World Health Organization (WHO) classification system were analyzed
Golden Retrievers were mostly associated with T-cell (57.9%) compared to B-cell lymphomas (42.1%) and Boxers were mostly associated with B-cell lymphomas (56.3%)
Summary
Lymphoma is regarded as the most common hematopoietic neoplasm of dogs and serves as a model of comparison with human non-Hodgkin lymphoma, due to their similarities in frequent histological and immunophenotypical types (Ponce et al, 2010; Vezzali et al, 2010; Curran and Thamm 2016). The histological classification according to the World Health Organization (WHO) (Jaffe et al, 2008) is constantly being updated (Swerdlow et al, 2016) and was adapted for veterinary medicine (Valli et al, 2002, 2011, 2013) This classification has been used to characterize the tumor in dogs and enables a comparison of results between human and canine lymphomas because it correlates morphology, immunophenotype, and clinical presentation. This in turn facilitates studies of comparative oncology (Vezzali et al, 2010). The results of the WHO classification system used by a group of pathologists with no specialization in hematopathology showed an 83% success rate, which demonstrates its efficacy for clinical practice (Valli et al, 2013)
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