Abstract
In this article, the biodegradation process and bone formation of a mineralized collagen reconstruction rod embedding in necrosis of human femoral head were investigated by imageological and histological methods. Computed radiography (CR) computerized tomography (CT), common pathological section and hard tissue section analysis were used to evaluated the dynamics of imageological and histopathological changes of femoral head, interface between the host bone and implant and the bone reconstruction process. The results showed that the density of rods increased closed to that of host bones after 1 year implanting, and the interface between them turns to blurring. Hard tissue grinding sections analysis showed osteocytes appearing in sparse bone trabecular and bone pit region, as well as a few vessels in the degraded dye powder matrix were noticed, indicating the new bone forming between the implants and host bones. Regular decalcified sections analysis showed scattered osteoclasts, multinucleated giant cells and fibrosis components existing in the degraded rod and the host bone trabecular. Degraded debris was endocytosed by giant cells, and vascular network formed around the boundaries of the implanted rod. The good osteointegration has been expressed by the interface between the implanted rod and the host bone becoming blurred. Histological results indicated that the implanted rod degradation process and new bones regeneration simultaneously occurred around the boundaries of embedding rod. New bone and host bone were hinged and co-existed.
Highlights
Non-traumatic femoral head necrosis is a kind of multiple diseases in persons from 30 to 50 years old
No space was found between host bone and reconstruction rod (Fig. 2), it was very difficult to separate the rod from host bone or take it out
New bone tissue and material when sectioning, commonly presented in de-calcified sample histology (Fig. 6). Both Computed radiography (CR) (Fig. 7) and computerized tomography (CT) (Fig. 8) showed that reconstruction rod contacted tightly with femoral head, femoral neck and intertrochanteric; the interface between the rod and host bone was very clear due to density difference between them after surgery
Summary
Non-traumatic femoral head necrosis is a kind of multiple diseases in persons from 30 to 50 years old. We collected the removed femoral head and femoral neck for histopathological examination and explored correlation of histology and imageological changes after mineralized collagen reconstruction rod implantation. The results can provide histological basis for clinical application of imageological method to assess the degradation of tissue engineered artificial bone and new bone formation.
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