Abstract
In our study the following inferences were made. Chronic calculous cholecystitis was seen in the age group of 41 to 50 years. A female preponderance was noted with male to female ratio of 2:3. The most common signs and symptoms were upper abdominal tenderness and right hypochondria pain. The mucosa showed ulceration in 63%, hyperplastic mucosa in 34% and metaplasia in 5%. 22% of cases showed mild (Grade-I) inflammation while 41 % of cases and 27% of cases showed moderate(Grade-2) and severe (Grade-3) inflammation respectively. 44 % of cases showed mild (Grade-I) fibrosis while 22% of cases and 15% of cases showed moderate (Grade-2) and severe (Grade-3) fibrosis. With increase 1n severity of inflammation and fibrosis, the total acid mucin content decreased while the neutral mucin content increased. Similar changes were observed in cases of metaplasia too.
Highlights
Biliary tract disorders affect a large percentage in Histopathology laboratory following of the world's population
When cholecytectomy specimens are subjected to histopathology examination, it created very important role for pathologists to diagnose the lesion that led to cholecystectomy
Chronic calculous cholecystitis was more common in the age group of 41 to 50 years, with a female majority, and more cases with moderate inflammation and mild fibrosis were identified in our study
Summary
Biliary tract disorders affect a large percentage in Histopathology laboratory following of the world's population. The muc1ns produced by both the lining cells and the neck mucous glands is mainly of sulphated acid type in physiological condition [1,2,3]. In contrast the cells of metaplastic glands contain nonsulfated acid mucin (sialomucin) and neutral mucin but little sulphated mucin. Histochemical stains for mucins carne s play an important role in the evaluation of the disease with clinical knowledge, the observations by histopathologic examination of gallbladder under light microscope and histochemical study of mucin present on the glands enable us to arrive at useful conclusions [4]. Several studies have suggested progress10n from metaplasia, through dysplasia, to adenocarcinoma of gallbladder. The existence of such a pathway has not been definitely proven [5]
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