Abstract
Melanoma is a very aggressive form of skin cancer in humans with a multifactorial etiology, resulting from interactions between...
Highlights
Melanoma is a very aggressive skin cancer responsible for thousands of deaths annually
Previous studies showed that Arctium lappa, popularly known as burdock, contains lignans and may exert cytotoxic specific effects against cancerous cells including prostate hyperplasia, leukemia, and certain cellular lineages of pancreatic cancer
We found that chronic treatment with A. lappa extract significantly reduced tumorigenesis, angiogenesis and mitotic index of cutaneous melanoma in C57BL/6 mice
Summary
Melanoma is a very aggressive skin cancer responsible for thousands of deaths annually. We evaluated A. lappa potential actions as an alternative cutaneous melanoma treatment in C57BL/6 mice. These results provide evidence that A. lappa contributes to improved host response against melanoma progression and that it may be an effective alternative approach to the treatment of cutaneous melanoma. Melanoma is a very aggressive form of skin cancer in humans with a multifactorial etiology, resulting from interactions between environmental, genetic and host factors. It affects both men and women, and it is more common in Caucasians due to their greater sensitivity to sun exposure [1,2]. Other processes have been implicated in the development of cancer including immune system evasion, genomic instability, and alterations in cellular metabolism
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