Abstract
Liver and kidney are vital organ that play an important role of detoxification and biotransformation of drugs and toxins. These organs are major target in safety assessment of preclinical toxicity and in oncogenicity studies with rodents.
Highlights
In Senegal, phytotherapy is an important part of traditional medicine and it is important to report the cases with lethal dose in experimental models
We found lesions such as vacuolar degeneration in the liver and the kidney of rats that received L. hastata at the dose of 500mg/kg/day
Methanolic extract of roots of L. hastata were responsible in our study for severe hepatic lesions and was lethal following administration according to a protocol of sub-acute toxicity
Summary
In Senegal, phytotherapy is an important part of traditional medicine and it is important to report the cases with lethal dose in experimental models. Liver and kidney are vital organ that play an important role of detoxification and biotransformation of drugs and toxins. These organs are major target in safety assessment of preclinical toxicity and in oncogenicity studies with rodents. Hepatic lesions are often described in phytotherapy and some components can even be responsible for fulminant hepatitis and conduce quickly to death [1] In Senegal, phytotherapy is an important part of traditional medicine and it is important to report the cases with lethal dose in experimental models.
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