Abstract

Objective To define the histopathologic risk factors for prognosis in patients with retinoblastoma treated by eyeball enucleation.Methods Clinicopathologic data of 125 patients with unilateral retinoblastoma were retrospectively reviewed,and all of them were treated by eyeball enucleation between 1995 and 2004 in Zhongshan Ophthalmic Center, Sun Yat-sen University.The Cox regression model was used for multivariate and univariate analysis.Results The overall five-year survival rate was 89% for the 125 pa-tients.The histopathologic factors significantly associated with poor prognosis for patients with retinoblastoma from univariate analysis included invasion to cut section of the optic nerve(χ2=114.150, P=0.000 ) ,sclerai in-vasion (χ2=35.080, P=0.000), orbital invasion (χ2=28.765, P=0.000) ,iris invasion (χ2=18.242, P=0.000), ciliary body invasion(χ2=11.495, P=0.001), corneal invasion (χ2=10.240, P=0.001)and factors independent-ly associated with poor prognosis from a multivariate analysis were postlaminary optic nerve invasion (P=0.045 ,wald value is 4.013 )and involvement of optic nerve to transsection line(P=0.000,wald value is37.559). Conclusion Massive choroidal invasion, scleral invasion, orbital invasion, postlaminary optic nerve invasion and optic nerve transsection line invasion were important prognostic factors in patients with retinoblastoma af-ter eyeball enucleation. Key words: Retinoblastoma; Prognosis; Histopathologic risk factors

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