Histopathologic Diagnosis of Diffuse Placental Chorangiosis in a Patient WHO Presented with Preeclampsia and Inevitable Abortion

Abstract

Reported cases of chorangiosis in the literature are few and its etiopathogenesis is not still not completely understood [1]. However, most cases are caused by prolonged placental under-perfusion and chronic hypoxia [1]. Chorangiosis is also referred to as “extreme villous hyper-vascularity”; it is diagnosed by “the presence of more than 10 capillaries in more than 10 terminal chorionic villi in several areas of the placenta”, usually in three or more microscopic high power fields [1]. Cases of chorangiosis are reportedly seen in up to 5–7% of examined placentas from infants admitted to newborn intensive care units for various reasons, with an attendant increase in neonatal morbidity and mortality [1]. One of the well-documented causes of chorangiosis is Preeclampsia [1], which is a known cause of placental hypoxia and hypoperfusion as seen in this index case.