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Abstract
The global burden of diabetes mellitus and its complications are currently increasing. Diabetic cardiomyopathy (DCM) is the main cause of diabetes mellitus associated morbidity and mortality; therefore, a comprehensive understanding of DCM development is required for more effective treatment. A disorder of epigenetic posttranscriptional modification of histones in chromatin has been reported to be associated with the pathology of DCM. Recent studies have implicated that histone deacetylases could regulate cardiovascular and metabolic diseases in cellular processes including cardiac fibrosis, hypertrophy, oxidative stress and inflammation. Therefore in this review, we summarized the roles of histone deacetylases in the pathogenesis of DCM, aiming to provide insights into exploring potential preventative and therapeutic strategies of DCM.
Highlights
Diabetes mellitus is a metabolic disease characterized by hyperglycemia
We comprehensively reviewed the roles of histone deacetylases (HDACs) in cellular processes relevant to Diabetic cardiomyopathy (DCM), aiming to discuss the implication of HDACs in the pathogenesis of DCM and provide insights into exploring potential preventative and therapeutic strategies of DCM
Previous studies suggested that factors possibly implicated in the pathogenesis of DCM include cardiac fibrosis, cardiac hypertrophy, oxidative stress, and inflammation, which may contribute to alterations in the pathogenic gene expression by epigenetic mechanisms to initiate the pathogenic changes in the target cells and organs [35]
Summary
Diabetes mellitus is a metabolic disease characterized by hyperglycemia. With the improvement of living standard, the incidence of diabetes mellitus continues to rise across the world [1]. HDACs have been implicated in numerous cellular processes relevant to DCM, which include cardiac fibrosis, hypertrophy, inflammation and oxidative stress [31].
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