Histone deacetylase inhibitors suppress IL-6 production by rheumatoid arthritis firoblast-like synoviocytes and macrophages via modulation of mRNA stability rather than blockade of NF-κB signalling

Abstract

Background and objectivesInterleukin 6 (IL-6) is a key inflammatory cytokine in the pathobiology of rheumatoid arthritis (RA) and biological therapies targeting the IL-6 receptor have shown clinical benefit. The production...