Abstract
How plant metabolic flux impacts gene expression to optimize plant growth and response to stress remains largely unknown. Here we show that Arabidopsis NAD+‐dependent histone deacetylase AtSRT1 negatively regulates plant tolerance to stress and glycolysis, but stimulates mitochondrial respiration rate. AtSRT1 interacts with Arabidopsis cMyc‐Binding Protein‐1 (AtMBP‐1), a transcriptional repressor produced by alternative translation of the cytosolic glycolytic enolase gene LOS2/ENO2. AtSRT1 is associated with chromatin of AtMBP‐1 targets LOS2/ENO2 and STZ/ZAT10 (both are master stress regulatory genes), reduces H3K9ac from the loci, and represses transcription of the genes. Over‐expression of both AtSRT1 and AtMBP‐1 had synergistic effects on glycolytic gene expression and enzyme activity and mitochondrial respiration. In addition, AtSRT1 could remove lysine acetylation from AtMBP‐1 protein and thereby enhance its stability in vivo. The results indicate that AtSRT1 has a function to coordinate primary metabolism and stress‐response by both epigenetic regulation and modulating transcriptional activity of AtMBP‐1.
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