Histone deacetylase-1 and -3 expression in human endometrium and mammary gland

Abstract

Reversible histone acetylation has been identified as major regulator of eukaryotic gene transcription: the removal of acetyl-groups from the amino-terminal end of core histones catalysed by histone deacetylases (HDACs) induces gene repression. Recently, it has been shown that inhibition of histone deacetylation enhances progesterone-induced decidualisation of human endometrial stroma cells. Furthermore, histone deacetylase inhibitors induced differentiation in breast cancer cells.