Abstract
Histone clipping was first discovered in the1960s and still is a lingering mystery. Considering the essential roles of histones inregulating eukaryotic transcription through the histone code, clipping is a post-translational modification that appeals to the imagination. In this issue of EMBO Reports, Marruecos and colleagues investigate histone H4 clipping during intestinal development (Marruecos etal, 2021), and are providing crucial clues to finally elucidate the intricacies of this elusive modification.
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