Abstract
Introduction: Breast carcinoma is the common malignant tumor in women accounting for 15% of cancer related deaths. Clinical history, examination and use of mammography has improved the diagnostic approach to breast cancer. Nottingham prognostication index is considered to be a useful marker that takes into consideration some of the important factors like tumor size, histologic grade and lymphnode stage. Aims and Objectives: 1. To study histomorphological distribution pattern of various invasive breast carcinoma. 2. To estimate prognosis by using Nottingham prognostic index score. Materials and Methods: One year six months descriptive study was performed which included all the invasive breast carcinoma cases comprising of mastectomy specimen with lymphnode sampling. Based on tumor size, histologic grade and lymphnode stage; Nottingham prognostic index score was calculated and cases were categorised into different prognostic group. Results: 68 cases were included in the study with 67 female patients and one male patient. Histopathologically, 80.88% were Infiltrating ductal carcinoma – not otherwise specified. Tumor size belonging to T2 in 66.17%. 45.58% showed no lymphnode involvement and 33.82% belonged to lymphnode stage N1. Majority (50%) belonged to histologic grade II. Nottingham Prognostic Index (NPI) score in 42.64% showed moderate prognosis. Conclusion: Histomorphological study showed commonest lesion to be Infiltrating Ductal carcinomanot otherwise specified and majority belonged to moderate prognosis category according to Nottingham Prognostic Index score. Keywords: Histomorphology, Infiltrating ductal carcinoma, Tumor size, Nottingham Prognostic index.
Highlights
Breast carcinoma is the common malignant tumor in women accounting for 15% of cancer related deaths
Clinical examination used in conjunction with diagnostic modalities like mammography and Fine needle aspiration cytology, can efficiently diagnose breast carcinoma
There are many prognostic factors and use of some of these factors like tumor size, lymphnode stage, histologic tumor grade help in calculating a prognostic score known as Nottingham Prognostic Index
Summary
Breast carcinoma is the common malignant tumor in women accounting for 15% of cancer related deaths. Nottingham prognostication index is considered to be a useful marker that takes into consideration some of the important factors like tumor size, histologic grade and lymphnode stage. Histologic grade and lymphnode stage; Nottingham prognostic index score was calculated and cases were categorised into different prognostic group. Conclusion: Histomorphological study showed commonest lesion to be Infiltrating Ductal carcinomanot otherwise specified and majority belonged to moderate prognosis category according to Nottingham Prognostic Index score. 5. Clinical management of breast carcinoma depends on various prognostic factors, some of the important ones being tumor size, lymphnode stage and histologic grade. Nottingham prognostication index (NPI), was first described in 1982 and takes into consideration the tumor size, lymphnode stage and histologic grade. It gives valuable information to the clinician/ surgeon to decide if postsurgery adjuvant chemotherapy is necessary in a given patient. 7
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
