HISTOMORPHOLOGICAL SPECTRUM OF OCULAR SURFACE SQUAMOUS NEOPLASIA: A 5 YEAR STUDY.

Abstract

Ocular surface squamous neoplasia encompasses the entire spectrum of epithelial dysplasias and neoplasia including squamous cell carcinoma. It may arise from ocular surface of conjunctiva, cornea and limbus. Purpose: The aim of this study is to demonstrate varying degrees of histomorphological spectrum in Squamous neoplasias of ocular surface. This is a Retrospective study conducted at Department Materials and Methods: of Pathology for a period of 5 years in Sarojini devi eye Hospital, Hyderabad, Telangana, India. The data collected was subjected to statistical tabulations and analysis was done. Results: The mean age of presentation was 46.39 years (6 to 82 years) with male preponderance (64.9%). The most common age group of presentation was 31-40 years (n =31, 22.62%) .The most common type of OSSN was invasive Squamous cell carcinoma seen in 37.22% (n =51) followed by Carcinoma in situ 20.43% (n =28). Out of 51 patients diagnosed with Squamous cell carcinoma, male patients were 34 (66.6%) and female patients were 17 (33.3%), among females diagnosed with SCC 13 cases(76.7%) were well differentiated type and remaining 4 cases(23.52) were moderately differentiated type. Only 1 male patient had Poorly differentiated type of Squamous cell carcinoma, 3 patients (5.8%) had inltrating tumor into surrounding tissues. 7 Patients (5.10%) diagnosed with OSSN were HIV positive. OSSN occurred in a relatively young Conclusion: age group with male preponderance possibly due to outdoor exposure . Based on Histopathology, Squamous cell carcinoma is the most common form of OSSN in the Asian Indian population.