Histomorphological Patterns of Endometrial Hyperplasia

Abstract

Background and Aims Endometrial hyperplasia is a pathological condition characterized by an increase in the endometrial gland to stromal ratio when compared to the normal proliferative endometrium. It is the precursor of endometrial carcinomamdashthe most common malignancy of female genital tract. The increased risk of endometrial hyperplasia is found to be more evident in women with abnormal uterine bleeding. Hence we decided to study the histopathological pattern of endometrial hyperplasia in women of different age groups.Methods All the endometrial biopsies with microscopic diagnosis of endometrial hyperplasia over a period of 1 year were retrieved from histopathology records. Information related to age and clinical diagnosis was noted from the accompanying laboratory request forms. Histological typing of endometrial hyperplasia was done depending on the new criteria used in the World Health Organization WHO classification.Results The present study included 40 cases n 40 of endometrial hyperplasia diagnosed by histopathological examination on endometrial biopsies. Age of the patients ranged from 21-70 years. About half of the patients 45 presented with abnormal uterine bleeding and were in the 5th decade of life. Non-atypical endometrial hyperplasia n 34 cases 85 was the most common histological type of endometrial hyperplasia.Conclusions Histopathological examination of endometrium is used for the diagnosis of abnormal uterine bleeding. Endometrial biopsy and curettage are the important sampling methods to detect endometrial hyperplasia. Hence vigilant screening of the endometrial samples plays an important role in the diagnosis and further management.