Abstract
Background & Objective:Leprosy is characterized by various clinicopathological forms depending on the host's body. Therefore, the correlation of histopathological findings with bacteriological index is helpful in diagnosing, classification, and monitoring the treatment. We aimed to analyze the histomorphological findings correlation with the bacteriological index in different types of leprosy. Then, study the histopathological spectrum of leprosy. Methods: We carried out a histomorphological study of skin biopsies obtained from 100 new patients tested clinically in OPD (Out Patients Department) on the basis and calculation of bacteriological index on a slit-skin smear. The histomorphological findings correlation with the bacteriological index was to be found in different types of leprosy.Results:In the histopathological studies, 52% of the patients were diagnosed with borderline tuberculoid (BT) followed by 20% with borderline lepromatous (BL), 13% with lepromatous leprosy (LL), 8% with tuberculoid (TT), 4% with histoid Hansen's disease, and 3% with mid-borderline (BB). On the clinical and histopathological examinations, correlation was found for 80% of the cases. Considering the correlation of histopathological features with the bacteriological index, 63% of the cases showed good correlation which was comparable with that of other studies. Conclusion:Because of the underlying symptoms of leprosy, there is a difference between different types of leprosy and the clinical and environmental perceptions. Thus, the correlation of clinical, histopathological, and bacteriological indices could be more helpful in the diagnosis of leprosy rather than considering only one parameter.
Highlights
Leprosy is recognized as a granulomatous disease caused by Mycobacterium leprae in which skin is mainly affected
In the histopathological studies, 52% of the patients were diagnosed with borderline tuberculoid (BT) followed by 20% with borderline lepromatous (BL), 13% with lepromatous leprosy (LL), 8% with tuberculoid (TT), 4% with histoid Hansen's disease, and 3% with mid-borderline (BB)
Because of the underlying symptoms of leprosy, there is a difference between different types of leprosy and the clinical and environmental perceptions
Summary
Leprosy is recognized as a granulomatous disease caused by Mycobacterium leprae in which skin is mainly affected. The pathogenesis of leprosy is complex and its clinicopathological manifestations are the result of hostparasite interactions (1, 2). The prevalence is declining, the disease continues to be the major cause of many public health problems. It was found that 211903 new cases of leprosy were diagnosed in 2010, globally (3). The worst affected countries were India and Brazil as well as other countries in Sub-Saharan Africa and Southeast Asia (4). Leprosy is characterized by various clinicopathological forms depending on the host's body. The correlation of histopathological findings with bacteriological index is helpful in diagnosing, classification, and monitoring the treatment. We aimed to analyze the histomorphological findings correlation with the bacteriological index in different types of leprosy.
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