Abstract
Background: Gall bladder diseases can be an incidental finding and when symptomatic, present with signs and symptom of cholecystitis and cholelithiasis. On histopathological examination however wide range of pathological changes are encountered including carcinoma. Several studies have been carried out to establish relationship of helicobacter infection with gallbladder diseases. This study tries to look at the frequency of risk factors, spectrum of histological changes and the relationship between different types of gallbladder diseases and helicobacter infection.Materials and Methods: Total of 500 gallbladder specimen received over the period of 24 months was included in the study. Bile culture and histopathological examination cholecystectomy were performed with routine hematoxylin and eosin stain and Giemsa stain.Results: Out of the 500 cases. Helicobacter was seen in 166(33%) of cases. Carcinoma was seen in 7 (1%) cases. Helcobacter infection was seen positive in 5/7 (71%) malignant cases which showed a statistically significant p value of 0.03.Conclusion: Cholecystitis is the most common gallbladder disease. All gallbladder carcinomas were incidental finding and were of lower grade and stage. Helicobacter infection was prevalent in variety of gallbladder pathology and had significant association with gallbladder carcinoma. However, definite relation between the helicobacter infection and gallbladder diseases cannot be concluded. DOI: http://dx.doi.org/10.3126/jpn.v4i8.11607 Journal of Pathology of Nepal; Vol.4,No.8 (2014) 617-622
Highlights
The histopathological entities encountered in gallbladder ranges from cholelithiasis on one end of the spectrum and carcinoma on another
Cholelithiasis accounts of more than 95% of all biliary tract diseases.[1]. It has an incidence of 11% in United States according to Framingham study[2] and is four times more common in women than in men with peak age Correspondence: Dr Geetika K.C., MD Department of Pathology, KIST Medical College, Imadole, Lalitpur Email Address: geetikakc@hotmail.com group of sixth and seventh decade of life.[3]
The aim of this study was to to study the frequency of risk factors associated with cholecystitis, the histomorphological spectrum of gallbladder diseases and attempted to find out its association with Helicobacter infection
Summary
The histopathological entities encountered in gallbladder ranges from cholelithiasis on one end of the spectrum and carcinoma on another. Seen are non-neoplastic epithelial alterations, non-neoplastic tumour like lesions, noninvasive epithelial lesion and carcinoma.l All of these are usually incidental finding, including carcinoma.[11]. Gall bladder diseases can be an incidental finding and when symptomatic, present with signs and symptom of cholecystitis and cholelithiasis. On histopathological examination wide range of pathological changes are encountered including carcinoma. Several studies have been carried out to establish relationship of helicobacter infection with gallbladder diseases. This study tries to look at the frequency of risk factors, spectrum of histological changes and the relationship between different types of gallbladder diseases and helicobacter infection
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