Abstract
It has also become increasingly necessary to diversify the production of cellulose for biomedical applications. In this study, cellulose-green-synthesized from Sesamum indicum (GSC)—was administered orally to rats for 14 days as follows: control, 100, 200 and 400 mg/kg GSC. The impact of GSC on the antioxidant status and histomorphology of the testes and epididymis were studied. GSC had no effects on organ weights and organosomatic indices. In the testes, GSC caused nonsignificant changes in superoxide dismutase, catalase, reduced glutathione and nitric oxide levels, whereas it significantly decreased glutathione peroxidase and malondialdehyde levels. In the epididymis, GSC significantly decreased superoxide dismutase and nitric oxide levels, but caused a significant increase in glutathione peroxidase and reduced glutathione levels. Furthermore, at ×200 magnification, testicular morphology appeared normal at all doses, however, extravasation of the germinal epithelium of the epididymis was observed at doses of 200 and 400 mg/kg GSC. Conversely, at ×400 magnification, spermatogenic arrest (testes) and chromatolytic alterations (epididymis) were observed at the higher doses (200 and 400 mg/kg GSC). This study reports on the effect of green-synthesized cellulose on testicular and epididymal histology and redox status and further extends the frontiers of research on cellulose.
Highlights
Cellulose and its derivatives have been identified as part of the group of isolated or synthetic nondigestible carbohydrates that could be designated as “generally regarded as safe” (GRAS) and used as a food additive [1]
Considering the widespread exposure of humans to cellulose and the limited data on its effect on male reproductive organs, the present study explored whether green-synthesized cellulose distorted redox homeostasis and morphology in the testes and epididymis of male Wistar rats
green-synthesized from Sesamum indicum (GSC) administered at the doses of 100, 200 and 400 mg/kg did not produce any effect on the absolute weights, organosomatic indices and total proteins of testes and epididymis of the treated rats
Summary
Cellulose and its derivatives have been identified as part of the group of isolated or synthetic nondigestible carbohydrates that could be designated as “generally regarded as safe” (GRAS) and used as a food additive [1]. Within the last few years, interest in the use of cellulose has heightened. Cellulose reinforces the dietary needs of some ruminants and termites, while in humans, it acts. The utility of cellulose in the textile and paper industries have long been recognized [2]. Natural cellulose is thermally unstable, incompatible with hydrophobic polymers and has high moisture retention. These constraints have raised the need to seek for nonconventional and inexpensive substitutes [3,4]. We had previously converted available cellulose into nanocellulose [5,6] or blended it with vermiculite polymer to yield composites with enhanced materiality [7]. The green synthesis approach, exploiting plant extracts as reducing agents, offer cost—and eco-friendly alternatives to the physical and chemical methods of synthesis
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