Abstract
Background - Kidney is involved in various pathological conditions ranging from non-neoplastic lesions to neoplastic diseases like renal cell carcinoma. Nephrectomy remains the treatment of choice for patient care in end stage renal diseases from various causes and neoplastic lesions. Objective: To study the histomorphological spectrum and frequency of various lesions in nephrectomy specimens. Material and methods:- A observational retrospective research study included 33 nephrectomy specimens in the department of pathology over a period of 4 years (April 2012 to April 2016).Clinical details and radiological findings were noted from records and clinico-histomorphological correlation was done. Results: - A total of 33 nephrectomy specimens were studied. Age distribution varied from 16 to 71 years with male to female ratio of 2:1.Benign lesions comprised of maximum cases (75.76%) while malignant lesion were present in 24.24% cases. Chronic nonspecific pyelonephritis was the predominant non-neoplastic finding followed by xanthogranulomatous pyelonephritis. Renal cell carcinoma was the most common malignant lesion in this study. Conclusion: Chronic nonspecific pyelonephritis leading to end stage renal disease is the commonest causative factor in our region ; may be due to consumption of hard water in rural areas. DOI: 10.21276/APALM.1111
Highlights
Kidney plays a vital role in excretion of waste product, water and electrolyte metabolism along with acid base balance, maintenance of blood pressure by secretion of renin-angiotensin and regulation of erythropoiesis by erythropoietin
Simple nephrectomy is indicated in patients with traumatic injury, end stage renal diseases resulting from obstructive uropathy, calculus disease, renovascular hypertension, chronic urinary tract infections and renal dysplasia
An indication of nephrectomy depends on the type of lesion, extent of damage, general condition of patient and status of contralateral kidney.[1,2]
Summary
Kidney plays a vital role in excretion of waste product, water and electrolyte metabolism along with acid base balance, maintenance of blood pressure by secretion of renin-angiotensin and regulation of erythropoiesis by erythropoietin. Renal diseases are responsible for great deal of morbidity than mortality. Nephrectomy in the form of partial or radical is now-a-days became a common procedure in surgical and urological practice. Simple nephrectomy is indicated in patients with traumatic injury, end stage renal diseases resulting from obstructive uropathy, calculus disease, renovascular hypertension, chronic urinary tract infections and renal dysplasia. An indication of nephrectomy depends on the type of lesion, extent of damage, general condition of patient and status of contralateral kidney.[1,2] gold standard treatment renal tumors is radical or partial nephrectomy.[3]. Kidney is involved in various pathological conditions ranging from non-neoplastic lesions to neoplastic diseases like renal cell carcinoma. Nephrectomy remains the treatment of choice for patient care in end stage renal diseases from various causes and neoplastic lesions
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
