Abstract
The research deals with the study of histomorphologic changes in the lymph nodes of rats arising from the lymphotropic and intramuscular administration of acidic peptidoglycan. The authors investigated histologic changes and applied the morphometric method including the determination of the average size of the lymph nodes, the size of the germinal zones, the density of the lymph nodules. It is stated that the restructuring of the lymph nodes during lymphotropic administration occurs at different times in comparison with its intramuscular administration. The lymphotropic method provides a relatively earlier and prolonged onset of an immunostimulating effect. This made it possible to conclude that the method of administering immunomodulators should differentiate depending on the phase and form of the disease progression.
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