Abstract
This review focuses on some of the basic structural alterations taking place in the aging central nervous system including cerebral neuroglial changes in both human and animal models. The survey compiled reports regarding cell loss in the cerebral cortex, the cerebellum and the brainstem. It focuses on some functional changes associated with nuclei degenerations, including the nucleus basalis (suspected to be at the origin of Alzheimer's disease). Microscopic changes reviewed include those associated with specific cell organelles and pigment depots in nerve and neuroglial cells. By this article, completing a series of reviews on Histology of Aging, the authors hope to educate students in order stimulate discussions and point out fields of most needed future research in this topic.
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